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Multi-State Modeling of Time-to-Event Phenotypes in Genome-Wide Cancer Prognosis Studies
Analyses of disease-free survival data in some types of cancer studies indicate that cohorts of patients treated for cancer are mixtures of cured individuals and individuals susceptible to experience a cancer related event. Cured individuals do not experience any disease related events, and eventually die due to other causes. Individuals who are not cured may die after experiencing a cancer recurrence or may die due to cancer without experiencing recurrence caused, for example, by adverse effects of cancer treatment. Cure status is partially latent. When time-to-first event is censored or the cause of observed death is unknown, the cure status is unknown. To model progression events with possibly masked causes of death, we consider a semi-Markov multi-state model including partially latent cured and not cured states. We propose inference methods which allow us to identify genetic markers associated with the risk of experiencing a disease related event and timing of disease events.
Date and Time
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Additional Authors and Speakers (not including you)
Yongho Lim
Memorial University
Candemir Cigsar
Memorial University
Language of Oral Presentation
English
Language of Visual Aids
English

Speaker

Edit Name Primary Affiliation
Yildiz Yilmaz Memorial University of Newfoundland