Aim: A meta-analysis of the clinical effectiveness and health economics of glaucoma control strategies in Sub-Saharan Africa (SSA). Methods: Searches were performed using several key databases. Search terms included: glaucoma, diagnosis, treatment, effectiveness, costs, cost-effectiveness and Sub-Saharan Africa.Effect size was the proportion of study participants with an intra-ocular pressure (IOP) ≤ 22 mm Hg. Results: A total of 5,658 records were examined with 48 papers identified. The sensitivity and specificity of diagnostic devices to detect glaucomatous changes ranged from 58.3% to 93.8% and from 82.4% to 96.8%, respectively. The effect size for glaucoma control strategies was: 0.39 for laser trabeculoplasty; 0.56 for drainage implant devices; 0.66 for medical management; and 0.73 for all other non-drainage surgical interventions. Conclusions: There is a need to collect clinical effectiveness and health economic data across SSA to better inform glaucoma control strategies.