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Estimation of Time-Dependent Predictive Accuracy in the Presence of Competing Risks
Evaluating a candidate biomarker or developing a predictive model score for event-time outcomes is frequently an important clinical goal. However, model development and assessment may be complicated in the presence of competing risks. The time-dependent incident/dynamic cause-specific (CS) area under the ROC curve (AUC) proposed by Saha and Heagerty (2010, Biometrics 66, 999-1011) is an appealing semi-parametric measure to capture the predictive performance of a biomarker and incorporate competing risks. We propose a local and a global non-parametric estimator for the time-dependent CS AUC from censored survival data in the presence of competing risks. The first proposed estimator is a local average of time-dependent CS AUCs. The second estimator is based on modelling the CS AUC as a function of t through fractional polynomials. We investigated the performance of the proposed estimators through both simulation and real-life data analysis.
Date and Time
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Additional Authors and Speakers (not including you)
Paramita Saha Chaudhuri
McGill University
Language of Oral Presentation
English
Language of Visual Aids
English

Speaker

Edit Name Primary Affiliation
Rajib Dey McGill University