Characterizing Outcome Distributions of Dynamic Treatment Regimes
The goal of this work is to better convey the evidence for or against clinically significant differences in patient outcomes induced by different dynamic treatment regimes (DTRs). In pursuit of this goal, we present a framework for computing and presenting prediction regions and tolerance regions for the outcomes of a DTR operating within a multi-objective Markov decision process (MOMDP), in order to better characterize the outcome distribution for patients who follow the regime. Our framework draws on two bodies of existing work, one in computer science for learning in MOMDPs, and one in statistics for uncertainty quantification. We review the relevant methods from each body of work, present our framework, and illustrate its use using data from the Clinical Antipsychotic Trials of Intervention Effectiveness (Schizophrenia). Finally, we discuss potential future directions of this work for supporting sequential decision-making.
Date and Time
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Langue de la présentation orale
Anglais
Langue des supports visuels
Anglais