A Non-parametric Estimator of Time-dependent AUC in the Presence of Competing Risks
Survival outcome with competing risks arises naturally in many clinical settings. For example, kidney transplant patients may die before experiencing adverse kidney and/or transplant-related outcomes (e.g. graft failure) or may experience adverse kidney and/or transplant-related outcomes. To identify and evaluate a candidate biomarker for its ability to accurately predict which patient would experience disease-specific adverse outcome and when, is an active research area. In particular, time-dependent prediction accuracy measures such as time-dependent ROC and AUC have been proposed for such competing risks settings. In our research, we adapt an existing non-parametric time-dependent AUC estimator for competing risks outcome. We show that the resulting estimator is intuitively meaningful and easy to evaluate even for a large dataset. We assess the properties of the estimator using extensive simulation studies and a real life kidney transplant data.
Session
Date and Time
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Langue de la présentation orale
Anglais
Langue des supports visuels
Anglais