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Two-Phase Designs Involving Auxiliary Outcomes
Two-phase response-dependent designs have been widely used in modern cohort studies to define sampling strategies which yield efficient estimators while respecting budgetary constraints. Large cohort studies are platforms that support a series of biomarker studies addressing distinct but sometimes related scientific questions. We consider the design of two-phase studies which exploit the information available from previous two-phase studies conducted in the same platform. We focus on the setting where the current study examines the relationship between a previously studied biomarker and a new outcome - the work is similar in spirit to the analysis of secondary outcomes in case-control studies. The phase I sample is defined to contain outcomes and auxiliary covariate data, along with the exposure variable in individuals selected in phase II of the earlier two-phase studies. We construct the optimal phase II subsampling scheme based on such phase I samples to achieve maximum efficiency.
Date and Time
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Co-auteurs (non y compris vous-même)
Richard Cook
University of Waterloo
Liqun Diao
University of Waterloo
Langue de la présentation orale
Anglais
Langue des supports visuels
Anglais

Speaker

Edit Name Primary Affiliation
Ce Yang University of Waterloo